General Information

  • ID:  hor000793
  • Uniprot ID:  Q5DW47
  • Protein name:  Corazonin
  • Gene name:  Crz
  • Organism:  Apis mellifera (Honeybee)
  • Family:  Corazonin family
  • Source:  animal
  • Expression:  In the adult brain, expressed in four neurons of the lateral protocerebrum project axons towards the retrocerebral complex.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SFSENMINDHRQPAPTNNNY
  • Length:  20(88-107)
  • Propeptide:  MVNSQILILFILSLTITIVMCQTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY
  • Signal peptide:  MVNSQILILFILSLTITIVMC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity).
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Crzr
  • Target Unid:  B7ZKE3
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5DW47-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000793_AF2.pdbhor000793_ESM.pdb

Physical Information

Mass: 268854 Formula: C98H145N31O35S
Absent amino acids: CGKLVW Common amino acids: N
pI: 5.45 Basic residues: 2
Polar residues: 9 Hydrophobic residues: 3
Hydrophobicity: -157.5 Boman Index: -7130
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 24.5
Instability Index: 5013.5 Extinction Coefficient cystines: 1490
Absorbance 280nm: 78.42

Literature

  • PubMed ID:  19576913
  • Title:  Mass Spectrometric Profiling of (Neuro)-Peptides in the Worker Honeybee, Apis Mellifera